It seems that chemotherapy with ICI may result in improved activation of APC, which elicits T-cell-related antitumor effect leading to the suppressed metastatic tumor growth, reducing the immunosuppressive M2 macrophage, Tregs and MDSCs population, and finally improving the expression of the IFNβ, and CCL5 and CXCL10 [204, 207, 209, 210]. The gene discussed is CXCL10; the disease is neoplasm.