Moreover, studies in BRAFV600E mutation replace V600 valine-driven YUMM1.1 and YUMM2.1 melanomas, and the carcinogen-induced murine colon adenocarcinoma MC38 models clarified the critical competence of anti-PD-1 or anti-PD-L1 treatment to provoke potent antitumor effects versus tumor tissue in experimental models [81]. The gene discussed is PDCD1; the disease is melanoma.