CD274 and esophageal squamous cell carcinoma: Similarly, evaluation of CD8+ T cell infiltration and expression of immune checkpoints, such as PD-1, PD-L1, PD-L2, and T cell immunoreceptor with Ig and ITIM domains (TIGIT) in 154 patients with primary esophageal squamous cells carcinoma (ESCCs) suggested that the number of PD-1+ TILs was positively correlated with CD8+ TILs [35].