In a fibrosarcoma mice model, administration of anti-CTLA-4 anti-body caused raised levels of the IFN-inducible enzyme 2′,5′-oligoadenylate synthetase (OAS), a positive regulator of anti-tumor response, in draining lymph nodes concurrent with augmented levels of IFNγ in tumor lysates [75]. The gene discussed is CTLA4; the disease is neoplasm.