Besides, the results of IF analysis showed co-localization of FOXC2 and STC1 in mouse tissues, as well as co-localization of STC1 and ITGB6 in mouse tissues (Supplementary Fig. 7A-B (IF assay detected the relationship of STC1 and FOXC2, STC1 and ITGB6 in mouse tumor tissues in two cell lines)). This evidence concerns the gene ITGB6 and neoplasm.