Tumor associated F4/80+ macrophages in mice inoculated with the MCA205 (p < 0.01), CT26 (p = 0.062) and EG7 (p < 0.0001) also expressed elevated levels of FcγRII when compared to matched splenic F4/80+ cells, with the FcγR A:I ratio similarly and significantly reduced in MCA205 (p < 0.01), CT26 (p < 0.01) and EG7 (p < 0.001) tumors (Fig. 6h). The gene discussed is DDX53; the disease is neoplasm.