Other studies in RCC patients upon treatment with sorafenib also revealed that high baseline levels of VEGF were related to poor prognosis [193], while serum levels of circulating neutrophil gelatinase-associated lipocalin (NGAL) and VEGF were powerfully supported prolonged PFS in RCC patients receiving sunitinib [194]. The gene discussed is LCN2; the disease is renal cell carcinoma.