ITGAE and neoplasm: Kim et al. found that signature genes of the wingless and Int-1(Wnt)/-catenin and transforming growth factor (TGF)-signaling pathways to be elevated in tumors with low numbers of CD69+CD103+ tissue-resident memory-like CD8+ TIL, which represent prominent tumor-specific immune response and hold promise as a potential therapeutic target in iCCA patients [33].