A Chinese group conducted an experiment in which cells were examined after being treated with laminin or transfected with plasmids containing siRNA targeted to the 67-kDa laminin receptor, and observed the induction of FasL expression and cytotoxicity in CCA cells via the mitogen-activated protein kinases - extracellular signal-regulated kinases (MAKP-ERK) pathway against Fas-sensitive Jurkat T cells [43]. The gene discussed is LAMB2; the disease is cholangiocarcinoma.