The atypical protein kinase C-iota (aPKC-i) / Ser59-phosphorylated specificity protein 1 (P-Sp1) / Snail signaling induced immunosuppression by producing immunosuppressive natural T regulatory–like CD4+CD25- cells in 64 CCA patients [40]. The gene discussed is PRKCI; the disease is cholangiocarcinoma.