CD274 and neoplasm: In this systematic review, we found that Wnt/-catenin, TGF-signaling routes, aPKC-i/P-Sp1/Snail Signaling, B7-H1/PD-1Pathway and Fas/FasL signaling pathways were connected to the malignant potential and contributed to tumor immune evasion by increasing TILs apoptosis.