Importantly, S100A4(+)/HIF-1α(−) tumor cells were recruited along the surface of host preexisting vessels in vascular-rich areas of non-Ps perinecrotic lesions, whereas high VEGFA mRNA expression was found in S100A4(+)/HIF-1α(+) GBM cells in the adjacent areas. The gene discussed is S100A4; the disease is neoplasm.