PDT and PTT-induced immunogenic cell death (ICD) is a particular form of cell death [18, 19], that is characterized by the release of tumor-associated antigens and damage-associated molecular patterns [20], such as the translocation of calreticulin (CRT) and pro-inflammatory cytokines [21, 22], stimulating an immune response [23]. The gene discussed is CALR; the disease is neoplasm.