NFKB1 and insomnia: Insomnia is involved in the regulation of hypothalamus–pituitary–adrenal axis and the sympathetic nervous system, both of which together with tilting the basal gene expression profile toward increased pro-inflammatory [40, 41], activating β-adrenergic signaling, and inducing the increases in NF-κB, inflammatory gene expression, proinflammatory cytokines production, and systemic inflammation markers [41].