The mechanism may be that GLP-1RA induce NHE3 (Na+ /H+ exchanger 3-) phosphorylated and activated, which can result in the reabsorption of filtered Na + increase in the proximal tubule [35, 36], which may improve renal hemodynamics in diabetes-associated glomerular hyperfiltration through overlapping and separate mechanisms, then helps to reduce albuminuria. This evidence concerns the gene SLC9A3 and diabetes mellitus.