C–C motif chemokine ligand 25 (CCL25), belongs to the subfamily of small cytokine CC genes and the product of this gene binds to chemokine receptor CCR9. CCR9-CCL25 axis is reported to play a critical role in breast cancer (BC) cell survival and low chemotherapeutic effect of cisplatin primarily via PI3K/Akt dependent fashion [19]. The gene discussed is CCR9; the disease is breast cancer.