Considering that the CT + TT genotypes of rs3200401 carriers had a higher concentration of total cholesterol in MI patients [32] and had a disease exacerbation among the cerebral ischemic stroke patients [31], we speculated that the lncRNA MALAT1 gene rs3200401 CT + TT genotypes may affect lipid disorders and aggravate the exacerbation in cerebral ischemia, leading to a higher incidence of MACCEs. This evidence concerns the gene MALAT1 and Cerebral ischemia.