To further delineate the impact of FK506 on blood glucose control, either alone or in combination with bupropion or naltrexone, the fasting plasma glucose and insulin values at time point 0 from the OGTT were applied to a homeostasis model assessment (HOMA) of insulin resistance (HOMA-IR) and pancreatic beta cell function (HOMA-β) (Fig. 3B,C). This evidence concerns the gene INS and Insulin resistance.