Interestingly, plasma Ninj1 was positively related to CHA2DS2-VASc score in AF patients with statistical significance (R = 0.230, P = 0.024) (Fig. 3), whereas plasma Ninj1 was non-significantly correlated with HAS-BLED score (R = 0.055, P = 0.597). This evidence concerns the gene NINJ1 and atrial fibrillation.