This normalization determines a top 20 gene list (Fig. 4) including mainly microRNA and small nucleolar RNA genes, favored by their short length (at most about a hundred bases); yet, despite its 12,036 bp length, the VHL gene is still included in this list, together with HIST1H2AC, a gene encoding for a nuclear protein responsible for the nucleosome structure [40], and OR8G1, a gene encoding for an olfactory receptor protein, known to be associated with breast, ovarian and pancreatic cancer [41]. This evidence concerns the gene VHL and familial pancreatic carcinoma.