PCDH11X and muscular disease: Conversely, at present the TTN-AS1 gene, encoding a lncRNA transcribed from the opposite strand of the TTN gene, is known to be primarily associated with myopathy and other cardiac and muscular diseases [42].; similarly the protocadherins (Pcdhs), which are predominantly expressed in the nervous system and constitute the largest subfamily of the cadherin superfamily of cell-adhesion molecules, are until now known to be mostly associated with epilepsy and central nervous system neoplasms and disorders [43, 44], but also with several other cancers [41, 44].