Therefore, it was hypothesized that six lncRNAs, GXYLT1P3, LINC00348, LOC101928131, A-33-p3340852, A-21-p0003442 and LOC644838, in the co-expression network may serve a considerable role in the progression of cSCC by regulating apoptosis induced by endoplasmic reticulum stress, cellular signal transduction and autophagy. This evidence concerns the gene GXYLT1P3 and skin squamous cell carcinoma.