CD8A and neoplasm: For example, lipid accumulation in myeloid-derived suppressor cells (MDSCs), dendritic cells (DCs), tumor-associated macrophages (TAMs), and CD8+ T cells have been demonstrated to skew these immune cells towards immunosuppressive and immune-escaping phenotypes in the TME (Herber et al., 2010; Al-Khami et al., 2017; Ma et al., 2019; Rabold et al., 2020; Su et al., 2020).