The enriched oxysterol in the TME can not only increase the recruitment of neutrophil (Raccosta et al., 2013) and MDSC (Baek et al., 2017) but also downregulate the antigen-presenting function of DCs (Villablanca et al., 2010) and the effector function of CD8+ T cells (Baek et al., 2017), resulting in the tumor immune evasion. The gene discussed is CD8A; the disease is neoplasm.