This CftrΔ9/Δ9 mouse model demonstrates that exon skipping could be a feasible strategy for selected CFTR mutations to reduce a severe CF phenotype, although further investigation in human-derived tissue models is required as has been done for CFTR exon 23 skipping for mutations p.Trp1282X (Kim et al., 2022) (Oren et al., 2021; Michaels et al., 2022). Here, CFTR is linked to cystic fibrosis.