Based on these findings and the exclusion of HEWL as the correct model protein, as well as the findings that Cin and PEA promoted the entrapment of intermediate species of HEWL (through structural, kinetics, and thermal stability studies) as a globular protein (Seraj et al., 2019), different in structure from tau and α-synuclein proteins, which are unstructured proteins, it was important to analyze the effect of the three volatiles compounds on the correct protein, directly related to the brain and the related neurodegenerative diseases concerned. Here, MAPT is linked to neurodegenerative disease.