The primary pathology of the CRF model is renal fibrosis, related to the abnormal changes of several signal pathways, such as TGF-β1/Smad, MAPK signaling, and GSK-3β/β-Catenin (Ma and Meng, 2019; Schunk et al., 2021; Zhou et al., 2021). Here, GSK3B is linked to renal fibrosis.