A previous cross-sectional study investigating the association between OSA and circulating ADAMTS13 levels [36] found no significant difference in ADAMTS13 levels between 58 OSA patients (receiving nasal CPAP therapy) and 25 sleep controls, which indicated the CPAP therapy may alleviate the increase in the circulating ADAMTS13 levels by OSA. This evidence concerns the gene ADAMTS13 and obstructive sleep apnea syndrome.