TP53 and B-cell chronic lymphocytic leukemia: Although present in 8% of monoclonal B lymphocytosis,26 CK ≥3 is associated with advanced stage disease, cases harboring unmutated IGHV genes (U-CLL), del(11q), TP53 aberrations [del(17p) and/or TP53 mutation], and telomere dysfunction.26–28