It has been recently reported that in almost 20% of patients with CK in CLL, even among those with more than 5 chromosomal aberrations (high CK), no TP53 aberration could be detected despite using high-sensitive detection methods, that is, targeted next generation sequencing.26 Whether CK in these cases is an independent biological phenomenon or closely related to a non-p53 dependent, still undefined, pathophysiologic mechanism, needs to be further investigated. Here, TP53 is linked to B-cell chronic lymphocytic leukemia.