Moreover, other members of our group identified coiled-coil domain containing 25 (CCDC25), apoptosis-inducing factor, mitochondrion-associated 3 (AIFM3) and cytokine-induced apoptosis inhibitor 1 (CIAPIN1) as potential secreted protein biomarkers in CCA (17–19). The gene discussed is CCDC25; the disease is cholangiocarcinoma.