In this study, we first analyzed the correlation between NER-related genes and the prognosis of ovarian cancer cases from the TCGA database and found that the high-expression levels of Helicase POLQ-like (HELQ), Xeroderma pigmentosum group A-binding protein2 (XAB2), and replication protein A2 (RPA2) were associated with the poor prognosis of ovarian cancer. The gene discussed is RPA2; the disease is ovarian cancer.