ELN and obesity due to melanocortin 4 receptor deficiency: Even though there is limited research on how acquired cardiovascular risk factor such as obesity and/or diabetes could affect the remodeling of elastic arteries, there is evidence of remodeling of elastin in adipose tissue of obese individuals and becoming more viscous in the settings of high-glucose levels (Spencer et al., 2011; Wang et al., 2015; Cocciolone et al., 2018).