Since Fetuin-A also alters the cardiac metabolism [14] and the overweight/obesity of rats receiving the HL diet is associated with hypertension and RAAS-mediated molecular alterations in renal Na+-transporting ATPases [1], the data from Figs. 1 and 2 allows us to propose that the Western diet HL can lead to a hepatocardiorenal syndrome, an emerging concept in pathology [16]. This evidence concerns the gene AHSG and obesity due to melanocortin 4 receptor deficiency.