VEGFA and neoplasm: The phenomenon of BV regression and its therapeutic implications were explored as early as the 1940s and 50s, roughly a half century prior to the discovery of the aforementioned markers of LECs that enabled the study of LV regression (Terry, 1942; Michaelson and Schreiber, 1956), with researchers subsequently proposing that modulation of vascular endothelial growth factor (VEGF) signaling pathways and other angiogenic pathways would prove fruitful in anti-tumor therapies (Kowanetz and Ferrara, 2006; Kong et al., 2017).