It has been reported that miR-377-3P mediated the functions of circPDK1 in renal cell carcinoma (RCC) by binding to the 3′ untranslated region (UTR) of Notch1, indicating a critical role of miRNA between circRNA and Notch1 signaling (Huang et al., 2020b). The gene discussed is NOTCH1; the disease is hereditary clear cell renal cell carcinoma.