Beneficial effects of ASTX on diabetes, together with or without conventional treatment methods, have been reported [32], including enhanced insulin sensitivity [33, 34], regulation of glucose metabolism [33, 35, 36], and reduction of blood glucose levels [37] in early diabetes, as well as decreased hyperglycemia [37–39], lipid peroxidation, ROS/oxidative stress [40–42], and inflammation [41–45] in diabetes. Here, INS is linked to diabetes mellitus.