The suggested role of mCXCR1 in the regulation of TGF-β content is supported by recent data highlighting the prominent role of the CXCL6/CXCR1 axis in the release of TGF-β by liver Kupffer cells both in patients with liver fibrosis and in a mouse model of carbon tetrachloride-induced chronic liver injury and fibrosis (49). This evidence concerns the gene TGFB1 and Hepatic fibrosis.