GATA1 and myelofibrosis: Although drugs that increase GATA1 in MKs, such as Aurora kinase inhibitors, have been shown to be effective in reduce fibrosis in myelofibrosis patients (58), it may be debated whether drugs, such as Reparixin, that increase GATA1 protein in a mouse model in which the transcription of the gene is reduced by deletion of its regulatory sequence, will be effective in patients where the GATA1 content is reduced by inefficient translation of GATA1 mRNA (39).