CXCR1 and pulmonary fibrosis: Similarly, the CXCR1/R2 inhibition exerted by ladarixin, a dual allosteric blocker of CXCR1/R2 structurally similar to Reparixin, has been shown to reduce neutrophil infiltration and collagen deposition in the bleomycin-induced mouse model of pulmonary fibrosis (27).