Consistently, in this study, we also found an increased total CAT expression, and we also firstly found that there was significantly decreased ECA-binding membrane galactosylated CAT of human HCC tissues compared to adjacent non-tumor tissues, and decreased as the malignancy of liver cancer increased accordingly, which suggest that both increased total CAT protein and decreased galactosylated CAT glycoprotein level might be involved in the development of HCC. This evidence concerns the gene CAT and neoplasm.