We found significantly decreased Erythrina cristagalli lectin (ECA) lectin-binding ability and ECA-binding membrane glycoproteins catalase (CAT) and prolyl 4-hydroxylase beta polypeptide (P4HB) from HCC tissues samples as potential candidates with diagnostic and/or metastasis prediction value for human HCC. The gene discussed is P4HB; the disease is hepatocellular carcinoma.