However, TNBC accounts for the most therapy-resistant subtype of heterogeneous basal-like tumors (15%–20% of all breast tumors), which frequently reflects a high mutational burden including tumor suppressor p53 (TP53 gene, 74.5%–82.8%), breast cancer type-1 and/or type-2 susceptibility gene (BRCA1, 1.96%–21.55%; BRCA2, 1.63%–18.10%), and phosphatidylinositol 3-kinase catalytic alpha polypeptide (PI3KCα, 8.6%–23.2%) (9, 14–16). This evidence concerns the gene BRCA1 and breast neoplasm.