VAV3 and gastric cancer: To better understand the impact of “RP11-138J23.1-HuR” on VAV3 mRNA stability, we treated BGC-823 and SGC-7901 cells with actinomycin D. Notably, qRT-PCR analysis showed that the half-life of VAV3 mRNA was significantly decreased in RP11-138J23.1- or HuR-downregulated GC cells (Figure 7A).