RPS6KB1 and esophageal squamous cell carcinoma: Some studies have shown that LY294002 inhibited the proliferation of ESCC cells not only through decreasing the levels of PI3Kp85α, p-Akt (Thr308) and p-p70S6K, but also increasing the expressions of p-Akt (Ser473) and PRAS40 (Thr246) (66).