As shown in Figures 4F–H, the combination of GroPIns and Venetoclax enhanced both apoptosis and Bax activation in leukemic cells co-cultured with HS-5 cells compared to single treatments (Figure 4A), albeit with less pronounced effects which are likely to be accounted for by the protective role of stromal cells on CLL cells. The gene discussed is BAX; the disease is B-cell chronic lymphocytic leukemia.