Along with an aberrant expression of anti-apoptotic molecules, CLL cells show high levels of intracellular phosphorylation mediated by the hyperactivation of several kinases downstream of the B-cell receptor, such as Lyn, Syk, Btk, PI3K, and AKT (50, 51). The gene discussed is AKT1; the disease is B-cell chronic lymphocytic leukemia.