PKM and neoplasm: To determine if this conversion plays a role in Cdk1-cyclin B complex formation, tumor cells were incubated with N,N’-diarylsulfonamide NCGC00185916 (DASA-58), a PKM2 activator that binds PKM2 subunits and promotes tetramer formation (7), after which the cells were monitored for effect on the Cdk1-cyclin B complex levels.