According to the Richter syndrome scoring system, patients with high-CK and/or CK2 show a 10-year risk of developing RT of 31%; patients with unmutated IGHV/11q deletion/TP53 disruption/>B Binet stage show a 10-year risk of 12%; while patients with mutated IGHV without CK and with wild type TP53 display a 10-year risk of developing RT of only 3% (60). This evidence concerns the gene TP53 and Richter syndrome.