NOTCH1 and diffuse large B-cell lymphoma: Somatic alterations involving genes of tumor suppression, cell cycle and proliferation pathways (i.e., mutations or disruptions of TP53, NOTCH1, MYC, and CDKN2A) are the main genetic clues of DLBCL-RT and can explain its aggressive disease kinetics and chemoresistance (30, 37, 38).