KLF4 and Hyperglycemia: Because, in our previous work, we established that intermittent high-glucose exposure to EC caused significant reduction in KLF2 and KLF4 level (Thakar et al., 2021) and such reduction in KLF2 and KLF4 were previously shown to be associated with EndMT (Moonen et al., 2015), we, therefore, measured the levels of KLF2 and KLF4 in EC exposed to intermittent hyperglycemia and OICR.