Studies from Amadoro and Calissano’s group reported that expression of NH 2 -truncated hTau in vitro and in vivo AD models caused dysregulation in the mitophagy pathway by enhancing the recruitment of Parkin and Ubiquitin-C-terminal hydrolase L1 (UCHL-1) to the mitochondria. The gene discussed is UCHL1; the disease is Alzheimer disease.