A recent study investigating the mechanism of mitophagy impairment in HD described that in differentiated striatal ST-Q111 cells (111 CAG repeats), mHTT impaired the initiation of mitophagy by increasing the stability of ULK1 and mTOR complex thereby maintaining ULK1 in its inactive form (Franco-Iborra et al., 2021). Here, ULK1 is linked to Huntington disease.