A study by Fang et al. showed that levels of mitophagy related proteins such as Bcl2L13, PINK1, BNIP3L/NIX, p-ULK1 (Ser555), p-TBK1, FUNDC1, AMBRA1, and MUL1 is downregulated in AD patient brains and iPSC-derived cortical neuronal cultures generated from AD patients, indicative of defective mitophagy pathway (Fang et al., 2019). Here, AMBRA1 is linked to Alzheimer disease.