PRKN and Parkinson disease: USP8 unlike the other DUBs positively regulates mitophagy pathway by selectively removing K6-linked ubiquitin conjugates from Parkin, a process that enhances Parkin recruitment to mitochondrial surface, inducing mitophagy but on the contrary, a recent study reported rescue of PD like phenotypes in PINK1 knockout (KO) of flies, which requires further elucidation (von Stockum et al., 2019).