As previously described (Huot et al., 2020a) and consistent with the reduced skeletal muscle mass, the mRNA expression of markers of protein catabolism such as Atrogin-1 and MuRF-1 was markedly increased in the muscle of C26 tumor hosts (+289%, p < 0.001; +912%, p < 0.001, respectively; Figure 3A) vs. TPP. Here, TRIM63 is linked to neoplasm.