At the present stage, there are no studies combining dynamic enhanced MRI with CA15-3, CYFRA21-1, and TFF1, but the combination of imaging examination and serologic testing is important for the secondary prevention of breast cancer, so the diagnostic efficacy of combining dynamic enhanced MRI with CA15-3, CYFRA21-1, and TFF1 was explored herein, with the results summarized as follows. This evidence concerns the gene TFF1 and breast cancer.