In this study, it was found that the combination of SGB and Dex can reduce the protein expression levels of GRP78, CHOP, and p-PERK, indicating that the combination of SGB and Dex can exert a lung-protective effect on obesity-related ALI through the PERK/CHOP pathway. Here, HSPA5 is linked to obesity due to melanocortin 4 receptor deficiency.