On further examining the effects of SGB combined with Dex on oxidative stress and endoplasmic reticulum stress in obesity-related ALI rats, the results showed that HFD + LPS significantly increased the level of MPO in the lung tissue, and reduced the activity of SOD and GSH-Px, while the use of SGB and Dex alone or the combination of SGB and Dex significantly reduced the level of MPO in the lung tissue and increased the SOD and GSH-Px activity in the lung tissue, with the combination of SGB and Dex being more effective (Figure 3(a)). Here, MPO is linked to obesity due to melanocortin 4 receptor deficiency.