The key findings of this study are (i) Consistent with a chronic phase of HIV infection, we observed a high frequency of CD8+ T-cells that responded to the viral variants with the identified mutations; in most of the individuals, these variants have not displaced the response to the WT epitopes, and mainly induced a response mediated by IFN-γ+ and cytotoxic molecules expression. The gene discussed is IFNG; the disease is HIV infectious disease.