Thevarajan (65) described an increase in the co-expression of HLA-DR and CD38 on CD8+ T cells before clinical recovery in a patient with COVID-19 (65), what is in line with our findings of a significant increase in HLA-DR expression on CD3+ and CD8+ cells over the first week in survivors and suggests the importance of HLA-DR in reaching the control over acute viral infections. This evidence concerns the gene CD38 and viral infectious disease.