The inflammatory pathways involved in COVID-19 include the interleukin-6/Janus kinase/STAT (IL-6/JAK/STAT), the interferon (IFN) cell signaling pathway, the TNFα-NF-κB inflammatory signaling pathway, the JAK/STAT pathway, the toll-like receptor (TLR) pathway, the antibody-mediated pathway, the Bruton tyrosine kinase (BTK) pathway, and the renin-angiotensin system (RAS) pathway (66). The gene discussed is BTK; the disease is COVID-19.