AKT1 and central nervous system cancer: Also, the fact that PI3K/AKT can switch among pathways that regulate metabolism and interaction with other proteins in immunes to alter their functions maladaptively just like in glioma, suggests that the pathway might be mediating other multiple underlying cascades leading epigenetic modifications (acetylation and methylation of histone) of immune cells and hastening the initiation and progression of gliomas.