(49) reported that uropathogenic Escherichia coli infection induces pyroptosis in bladder urothelial cells and that they secrete IL-1 and IL-18 in the exosome form, thus promoting the migration process of mast cells, in which mast cells secrete trypsin, further exacerbating the disruption of normal urethral barrier function, thus aggravating urethral infection. The gene discussed is IL18; the disease is escherichia coli infection.