Inhibiting CRL4CDT2 by CDT2 knockdown could be an effective way in eliminating the cells of cutaneous squamous cell carcinoma (cSCC) than targeting CRL4 alone due to its role in cell-cycle progression and genomic stability, and loss or low levels of DTL would lead to serious DNA damage (26). The gene discussed is IL17RB; the disease is cutaneous squamous cell carcinoma.