DTL and melanoma: CDT2 is an indispensable molecule for melanoma cells to proliferate and inhibit the CRL4CDT2 complex by pevonedistat [a specific inhibitor of the NEDD8-activating enzyme (NAE)], which attenuates the function of cullin E3 ligases and inhibits melanoma by inducing DNA re-replication and senescence through the stabilization of p21 and SET8, the CRL4CDT2 substrates (27).