CDK1 and hepatocellular carcinoma: We found that cell cycle-related genes, say, CDK1, MCM2, CDC45, and MCM6, showed significant positive associations with DTL expression (all r > 0.8, p < 0.05, Figure 4B), and these cell cycle-related genes, which show positive correlations with the DTL gene, were mostly risk factors for HCC patients (Figure 4B).