Interestingly, some senescent cells can secrete factors that create an immunosuppressive environment to promote tumor growth, and Toso et al. found that SASP factors produced by senescent prostate cells were immune-suppressive cytokines, such as CXCL2 and GMCSF, which are typically activated by signal transducer and activator of transcription 3 (STAT3) (12). Here, STAT3 is linked to neoplasm.