Based on the minimum criterion (Lambda.min = 0.0146), 9 genes (CHEK1, DEPDC1B, FANCI, MCM10, NCAPG, PARPBP, PLK4, RAD51AP1, and RFC4) that can effectively predict the prognosis of COAD were obtained by further dimensionality reduction of 34 genes via LASSO regression, as shown in Figure 4(a), and a prediction model based on the signatures of the 9 genes was constructed, as presented in Figure 4(b). This evidence concerns the gene PLK4 and colon adenocarcinoma.