SIRT3 and diabetic cardiomyopathy: Furthermore, OGG1 has been implicated in the development of DXB-induced cardiomyopathy in Sirt3-KO mouse model [5], in the prevention of mtDNA damage after abdominal aortic constriction [35], in the diabetic cardiomyopathy in mice [36], and in the end-stage cardiomyopathy in humans [2], implying that it may have an overall role in cardiac homeostasis.